[os-tee-uh-klast] /ˈɒs ti əˌklæst/
Cell Biology. one of the large multinuclear cells in growing bone concerned with the absorption of osseous tissue, as in the formation of canals.
Surgery. an instrument for effecting osteoclasis.
a surgical instrument for fracturing bone
a large multinuclear cell formed in bone marrow that is associated with the normal absorption of bone
osteoclast os·te·o·clast (ŏs’tē-ə-klāst’)
A specialized bone cell that absorbs bone, allowing for the deposition of new bone and maintenance of bone strength. Osteoclasts secrete enyzmes that dissolve the matrix of old bone tissue and acids that dissolve bone salts, which contain calcium and phosphorus. Except in growing bone, the rate of bone deposition and bone absorption equal each other so that bone mass remains constant. A mass of osteoclasts absorbs bone from the outer surfaces inward for about three weeks. The osteoclasts are then converted into osteoblasts that form new bone to fill in the cavities. See also osteoblast.
- Osteoclast-activating factor
osteoclast-activating factor n. A lymphokine that stimulates bone resorption and inhibits bone collagen synthesis.
osteoclastoma os·te·o·clas·to·ma (ŏs’tē-ō-klā-stō’mə) n. See giant cell tumor of bone.
[os-tee-uh-kohp] /ˈɒs ti əˌkoʊp/ noun, Pathology. 1. severe pain in the bones, especially that occurring in syphilitic persons.
osteocranium os·te·o·cra·ni·um (ŏs’tē-ō-krā’nē-əm) n. The fetal cranium after ossification of the membranous cranium has advanced to firmness.