Adult T cell leukemia-lymphoma: Abbreviated ATL. A malignancy of mature T lymphocytes (T cells) with its onset in adulthood caused by infection with the human T-lymphotropic virus type 1 (HTLV-1) and characterized by circulating malignant T-lymphocytes, skin lesions, lymphadenopathy (enlarged lymph nodes), hepatosplenomegaly (enlarged liver and spleen), hypercalcemia (high blood calcium), lytic (“punched out”) bone lesions, and a tendency to infection. There are four categories of ATL, based on the aggressiveness of the disease — smoldering, chronic, lymphomatous, and acute. ATL is a variant of non-Hodgkin’s lymphoma.
See also: Human T-lymphotropic virus.
- Adult-onset Still disease
Adult-onset Still disease: Although Still disease was first described in children, it is known to begin in adults (rarely). Of all patients with Still disease, 100% have high intermittent fever; 100% have joint inflammation and pain, muscle pain with fevers, and develop persistent chronic arthritis. Ninety-five percent (95%) have the faint salmon-colored skin rash. Eighty-five […]
- Advance directives
Advance directives: These directives pertain to treatment preferences and the designation of a surrogate decision-maker in the event that a person should become unable to make medical decisions on their own behalf. Advance directives generally fall into three categories: living will, power of attorney and health care proxy. LIVING WILL: This is a written document […]
- Advance medical directives
This is the third type of advance directive. Individuals may draft legal documents providing power of attorney to others in the case of incapacitating medical condition. The durable power of attorney allows an individual to make bank transactions, sign Social Security checks, apply for disability, or simply write checks to pay the utility bill while […]
- Advanced maternal age
Advanced maternal age: Usually defined as age 35 or more for the mother at the time of delivery of her baby. Advanced maternal age predisposes to Down syndrome (trisomy 21). The risk of having a Down syndrome baby rises with maternal age. It essentially doubles from 1 in 725 at maternal age 32 to 1 […]
- Advanced paternal age
Advanced paternal age: A man who is age 40 years or older at the time of conception. (There is no universally accepted definition of advanced paternal age but this criterion is often used in genetic counseling.) Advanced paternal age is associated with an increased risk of new mutations in the offspring. This risk for genetic […]