Drugs, teratogenic
Drugs, teratogenic: A teratogen is an agent that can disturb the development of the embryo or fetus. Teratogens halt the pregnancy or produce a congenital malformation (a birth defect). Classes of teratogens include radiation, maternal infections, chemicals, and drugs.
Drugs that are capable of acting as teratogens include:
ACE (angiotensin converting enzyme) inhibitors such as:
benazepril (Lotensin),
captopril (Capoten),
enalapril (Vasotec),
fosinopril sodium (Monopril),
lisinopril (Zestril, Prinivil),
lisinopril + hydrochlorothiazide (Zestoretic, Prinzide),
quinapril (Accupril) and
ramipril (Altace).
Acne medication isotretinoin (Accutane, Retin-A).
Alcohol ingested chronically or in binges.
Androgens (male hormones).
Antibiotics tetracycline (Achromycin), and doxycycline (Vibramycin), and streptomycin.
Anticoagulant (blood-thinner) warfarin (Coumadin).
Anticonvulsants (seizure medications) such as:
phenytoin (Dilatin),
valproic acid (Depakene, Valprotate),
trimethadione (Tridione),
paramethadione (Paradione), and
carbamazepine (Tegretol).
Anti-depressant drug lithium (Eskalith, Lithob).
Antimetabolite/anticancer drugs methotrexate (Rheumatrex) and aminopterin.
Antirheumatic agent and metal-binder (chelator) penicillamine (Ciprimene, Depen).
Antithyroid drugs such as:
thiouracil/propylthiouracil and
carbimazole/methimazole.
Cocaine.
DES (diethylstilbestrol), a hormone.
Thalidomide (THALOMID) which was approved by the FDA for the treatment of a complication of leprosy (erythema nodosum leprosum).
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