Goodman syndrome
A genetic syndrome characterized by acrocephalosyndactyly — birth defects involving the head and face and the fingers. The craniofacial features are essentially those of acrocephaly while the finger abnormalities include polydactyly (extra fingers), syndactyly (fusion of the fingers), clinodactyly, and ulnar deviation (with the fingers deviated laterally, toward the ulnar bone). The syndrome is inherited as an autosomal recessive trait (unlike most forms of acrocephalosyndactyly which are autosomal dominant traits).
The syndrome was described in 1979 by the pioneering American-Israeli medical geneticist Richard M. Goodman and his colleagues who called it acrocephalopolysyndactyly IV (ACPS IV). Today it is sometimes called Goodman syndrome.
Read Also:
- Goodpasture syndrome
An autoimmune disease characterized by a combination of lung and kidney disease. Hallmarks of the disease are pulmonary hemorrhage (bleeding in the lungs) and glomerulonephritis (inflammation of the glomerulus) due to severe inflammation in the basement membranes of the alveolus of the lung and the glomerulus in the kidney, with the formation of antibodies to […]
- Gooseflesh
A temporary local change in the skin when it becomes rougher due to erection of little muscles, as from cold, fear, or excitement. The chain of events leading to this skin change starts with a stimulus such as cold or fear. That stimulus causes a nerve discharge from the sympathetic nervous system, a portion of […]
- Goose bump
A temporary local change in the skin when it becomes rougher due to erection of little muscles, as from cold, fear, or excitement. The chain of events leading to this skin change starts with a stimulus such as cold or fear. That stimulus causes a nerve discharge from the sympathetic nervous system, a portion of […]
- Gorham disease
Also called disappearing bone disease. Extensive loss of calcium from a single bone so that it cannot be seen on x-ray. Any bone can be involved but the upper arm, shoulder, and jaw are most frequent. This type of selective decalcification is sometimes associated with the presence of an hemangioma, a knot of distended blood […]
- Gorlin syndrome
The nevoid basal cell carcinoma syndrome, a genetic disorder inherited in an autosomal dominant manner and characterized by a broad face, rib malformations, and an extraordinary predisposition to basal cell carcinoma, a type of skin cancer. The gene for Gorlin syndrome has been mapped to chromosome 9 and has been identified as PTCH, the human […]