An inborn error of metabolism associated with an offensive body odor, the smell of rotting fish, due to the excessive excretion of trimethylaminuria (TMA) in urine, sweat, and breath. Persons with TMA may experience tachycardia (fast heart rate) and severe hypertension (high blood pressure) after eating cheese (which contains tyramine) and after using nasal sprays containing epinephrine. TMA is caused by a mutation (change) in the gene for an enzyme, flavin-containing monooxygenase-3 (FMO3) encoded by a gene on chromosome #1. The FMO3 enzyme metabolizes tyramine (which is in cheese). The syndrome is associated with various psychosocial reactions, including social isolation, clinical depression and attempted suicide.
- Syndrome, floppy baby
A general medical reference to an abnormal condition of newborns and infants manifested by inadequate tone of the muscles. It can be due to a multitude of different neurologic and muscle problems. See also Hypotonia.
- Syndrome, fragile X
The most common heritable form of intellectual disability, occurring in about one in five thousand males and a smaller percentage of females. Characteristics of Fragile X syndrome in boys include prominent or long ears, a long face, delayed speech, large testes (macroorchidism), hyperactivity, tactile defensiveness, gross motor delays, and autistic-like behaviors. Much less is known […]
- Syndrome, Frey
Sweating on one side of the forehead, face, scalp, and neck occurring soon after ingesting food as a result of damage to a nerve that goes to the large saliva gland in the cheek (the parotid gland). Frey syndrome is the most common cause of sweating after eating (gustatory sweating). Gustatory sweating is also a […]
- Syndrome, Gelineau
A neurological disorder marked by a sudden recurrent uncontrollable compulsion to sleep. Named for a French neurologist, JBE Gelineau (1859-1906). Also known as narcolepsy. The disorder is often associated with cataplexy (a sudden loss of muscle tone and paralysis of voluntary muscles associated with a strong emotion), sleep paralysis (immobility of the body that occurs […]
- Syndrome, Gerstmann-Straussler-Scheinker