T-8 cells
T cells that express the CD8 transmembrane glycoprotein (CD8+ T cells). They close down the immune response after invading organisms are destroyed. Suppressor T cells are sensitive to high concentrations of circulating lymphokine hormones, and release their own lymphokines after an immune response has achieved its goal. This signals all other immune-system participants to cease their attack. Some memory B-cells remain after this signal to ward off a repeat attack by the invading organism. Also known as T-suppressor cells.
See also CD8, T cells; T lymphocytes, cytotoxic.
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Treatment designed to destroy T cells, which play an important role in the immune response. Elimination of T cells from a bone marrow graft from a donor may reduce the chance of graft-versus-host disease (an immune reaction against the recipient’s tissues).
- T-cell leukemia
A disease in which certain cells of the lymphoid system called T lymphocytes or T cells are malignant. T cells are white blood cells that normally can attack virus-infected cells, foreign cells, and cancer cells and produce substances that regulate the immune response.
- T-cell lymphoma
A disease in which cells in the lymphoid system called T cells (or T lymphocytes) become malignant. T-cell lymphomas account for a minority (about 15%) of non-Hodgkin lymphomas in the US and are more common in Asia. The T-cell lymphomas are highly diverse and include lymphoblastic lymphoma (mainly in children and adolescents, where they account […]
- T-cell receptor
A device used by T cells for recognizing specific antigens. T cells have receptors that are activated exclusively by a target antigen.
- T-helper cell
those that activate other T cells to achieve cellular inflammatory responses; and those that drive B cells to produce antibodies in the humoral immune response. These two classes of response are generally incompatible with one another and require coordination by substances called cytokines to promote one response while dampening the other. The HIV virus attacks […]