noun, Pathology.
a severe anemia caused by the diminution or absence of stomach acid secretion, with consequent failure of the gastric mucosa to secrete the intrinsic factor necessary for the absorption of vitamin B 1 2 , characterized by a great reduction in the number of red blood cells and an increase in their size.

pernicious anemia n.
A severe form of anemia most often affecting older adults, caused by failure of the stomach to absorb vitamin B12 and characterized by abnormally large red blood cells, gastrointestinal disturbances, and lesions of the spinal cord. Also called Addison’s anemia, malignant anemia.


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