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a chronic disease characterized by enlargement of the bones of the head, the soft parts of the feet and hands, and sometimes other structures, due to excessive secretion of growth hormone by the pituitary gland.
Historical Examples

acromegaly is characterised by abnormal growth, chiefly in the bones of the head, face, and extremities.
Degeneracy Eugene S. Talbot

In this case also the resulting ductless gland is still of functional importance, for disease of it is associated with acromegaly.
The Origin of Vertebrates Walter Holbrook Gaskell

Not rarely does it happen that acromegaly attacks the side most deficient in nerve supply.
Degeneracy Eugene S. Talbot

Indeed, as Marie has said, giantism is acromegaly occurring during the period of adolescence.
Degeneracy Eugene S. Talbot

Hypertrophy of the gland is directly associated with certain diseases, such as giantism and acromegaly.
The Mystery of Space Robert T. Browne

a chronic disease characterized by enlargement of the bones of the head, hands, and feet, and swelling and enlargement of soft tissue, esp the tongue. It is caused by excessive secretion of growth hormone by the pituitary gland Compare gigantism

“gigantism due to activity of pituitary after normal growth has ceased,” 1886, from French acromégalie, from medical Latin acromegalia, from Greek akron “extremity” (see acrid) + megas “great” (fem. megale; see mickle). Said in contemporary literature to have been coined 1885 by French physician Dr. Pierre Marie.

acromegaly ac·ro·meg·a·ly (āk’rō-měg’ə-lē)
A disorder marked by progressive enlargement of the head, face, hands, feet, and chest due to excessive secretion of growth hormone by the anterior lobe of the pituitary gland. Also called Marie’s disease.


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  • Acromelia

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  • Acromelic

    acromelic acromelic ac·ro·mel·ic (āk’rō-měl’ĭk) adj. Of or affecting the terminal part of a limb.

  • Acrometagenesis

    acrometagenesis acrometagenesis ac·ro·met·a·gen·e·sis (āk’rō-mět’ə-jěn’ĭ-sĭs) n. Abnormal development of the extremities resulting in deformity.

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