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to make indifferent or hostile:
By refusing to get a job, he has alienated his entire family.
to cause to be withdrawn or isolated from the objective world:
Bullying alienates already shy students from their classmates.
to turn away; transfer or divert:
to alienate funds from their intended purpose.
Law. to transfer or convey, as title, property, or other right, to another:
to alienate lands.
Contemporary Examples

Many are alienated from their families already and defiance is part of their motive for leaving.
Western Jihadists in Syria Threaten to Bring Their War Back Home Maajid Nawaz April 26, 2014

Non-college whites are the most alienated and pessimistic group in the electorate and also the most nationalist.
Defend Capitalism? David Frum July 17, 2012

As a result, our young people are alienated like no generation before them.
The ‘Yobs’ Are the Problem Francis Gilbert August 10, 2011

Not surprisingly, this has alienated independents, women, and young voters outside the conservative tribe.
The Case for Crazy: What the GOP Would Learn by Picking Rick Santorum John Avlon March 15, 2012

As it happens, whites without a college degree are the most alienated of all measured voting blocs.
Bain: The Debate You Have When You Don’t Have Ideas David Frum July 13, 2012

Historical Examples

I think not; you have blighted her confidence and alienated her affections.
Searchlights on Health: Light on Dark Corners B.G. Jefferis

I know not any of the number to be alienated from the true faith.
The Rise of the Hugenots, Vol. 1 (of 2) Henry Martyn Baird

To be alienated from him would be the bitterest grief which life could bring.
Flaming June Mrs. George de Horne Vaizey

She was helplessly conscious of the result: her husband was alienated from her.
Romola George Eliot

My alienated affections wandered, and I was unfaithful to Marion.
Tono Bungay H. G. Wells

verb (transitive)
to cause (a friend, sympathizer, etc) to become indifferent, unfriendly, or hostile; estrange
to turn away; divert: to alienate the affections of a person
(law) to transfer the ownership of (property, title, etc) to another person
v.

1540s, “make estranged” (in feelings or affections), from Latin alienatus, past participle of alienare “to make another’s, estrange,” from alienus “of or belonging to another person or place,” from alius “(an)other” (see alias (adv.)). Related: Alienated; alienating.