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unable to sit or stand still; fidgety:
The children were bored and antsy.
apprehensive, uneasy, or nervous:
I’m a little antsy since hearing those storm warnings.
Contemporary Examples

Nevertheless, Daum eventually got antsy for something slightly busier.
My Real Estate Obsession Jacob Bernstein May 11, 2010

But most people I talk to are generally on my half of this parking lot–not as antsy as I am, but not into lingering.
Are You a Restaurant Lingerer? Michael Tomasky March 27, 2013

Handlers bring the puppies down in waves to prevent them from getting too tired, freaked out, or antsy while filming.
‘The Puppy Bowl’: The Super Bowl’s Fiercest Rival Lori-Lee Emshey February 1, 2014

So that’s Eisenberg: antsy, discomfited, and still answering to Mom.
‘The Social Network’s’ Reluctant Star Anna David September 25, 2010

But following her second year, she says she “got antsy” and was ready to move on from classrooms and into audition rooms.
‘Orange Is the New Black’ Star Taylor Schilling on Her Path to Prison Marlow Stern July 29, 2013

Finally, he burst out with an antsy, “Come on, I want to go to war!”
War Games: Microsoft Invades Liechtenstein for Halo 4 Blowout Alex Klein November 7, 2012

Historical Examples

“Tell the truth, I’m sort of antsy to get back,” Joe Kivelson said.
Four-Day Planet Henry Beam Piper

Give the suits something to occupy themselves with—otherwise they get antsy and stir up trouble.
Makers Cory Doctorow

adjective antsier, antsiest
(informal) restless, nervous, and impatient
adj.

1838, American English, from plural of ant + -y (2); probably reflecting the same image as the slang expression have ants in (one’s) pants “be restless and fidgety” from a century later. Related: Antsiness.

adjective

In an anxious, disturbed state; nervous; jittery: But when things are quiet, I get antsy
Sexually aroused; lustful; hot