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holoprosencephaly hol·o·pros·en·ceph·a·ly (hŏl’ō-prŏs’ěn-sěf’ə-lē, hō’lō-)
Failure of the forebrain to divide into hemispheres or lobes causing insufficient development of facial characteristics such as the nose, lips, and palate; in severe cases, cyclopia can occur.


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