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marriage or cohabitation between two people from different racial groups, especially, in the U.S., between a black person and a white person:
In 1968 the Supreme Court ruled unanimously that state laws prohibiting miscegenation were unconstitutional.
sexual relations between two people from different racial backgrounds that results in the conception of a mixed-race child.
Contemporary Examples

Yes, he does say something about American society, which so frowned on miscegenation in the 1870s.
The Man Who Made America: Simone Winchester Talks New Book Eric Herschthal October 16, 2013

The miscegenation Ball was an exception in its otherwise bland, though proficient, catalog.
How a Racist Newspaper Defeated Lincoln in New York in the 1864 Election Harold Holzer May 1, 2013

miscegenation would follow and a mongrel race would be the result.
Up From History, Part 4 David Frum February 3, 2013

The major theme defining our new American century is miscegenation.
George Zimmerman, Hispanics, and the Messy Nature of American Identity Ilan Stavans April 5, 2012

Historical Examples

He calls attention to such injustices as miscegenation, lynching, unfairness of the courts, and discrimination in traveling.
The Journal of Negro History, Vol. I. Jan. 1916 Various

Nature, though eager for cross-fertilisation, abhors ‘miscegenation’ with all the bitterness of an American politician.
The Evolutionist at Large Grant Allen

When she was indicted last spring for miscegenation, she swore in court that she was not a white woman.
Southern Horrors Ida B. Wells-Barnett

But he has never sunk the contempt, and the contempt saves him from any general practice of miscegenation.
Problems of the Pacific Frank Fox

The inflow of white blood was small, and much of what did come lost itself in the dismal swamp of miscegenation.
The Rising Tide of Color Against White World-Supremacy Theodore Lothrop Stoddard

Among the Dravidians, especially, there are many castes which trace their origin to miscegenation.
India, Its Life and Thought John P. Jones

noun
interbreeding of races, esp where differences of pigmentation are involved
n.

“interbreeding of races,” 1864, coined irregularly in American English from Latin miscere “to mix” (see mix (v.)) + genus “race” (see genus).

miscegenation mis·ceg·e·na·tion (mĭ-sěj’ə-nā’shən, mĭs’ĭ-jə-)
n.
Marriage or sexual relations between individuals of different races.