Adiponectin: A protein hormone produced and secreted exclusively by adipocytes (fat cells) that regulates the metabolism of lipids and glucose. Adiponectin influences the body’s response to insulin. Adiponectin also has antiinflammatory effects on the cells lining the walls of blood vessels.
High blood levels of adiponectin are associated with a reduced risk of heart attack. Low levels of adiponectin are found in people who are obese (and who are at increased risk of a heart attack).
Adipocytes produce and secrete a number of proteins, including leptin, adipsin, properdin, and tumor necrosis factor (TNF). An adipose tissue-specific factor was isolated and termed APM1 (AdiPose Most abundant gene transcript 1). The protein product of APM1 is adiponectin. The APM1 gene maps to chromosome 3q27.
Adipose: Fatty. Adipose refers to tissue made up of mainly fat cells such as the yellow layer of fat beneath the skin.
- Adipose most abundant gene transcript 1
Adipose most abundant gene transcript 1: Abbreviated APM1. The APM1 gene encodes the hormone adiponectin.
Adjacent: Lying nearby. Related terms include superjacent, subjacent, and circumjacent. From ad-, near + the Latin jacere, to lie = to lie near.
Adjuvant: A substance that helps and enhances the effect of a drug, treatment, or biologic system.
- Adjuvant chemotherapy
Adjuvant chemotherapy: Chemotherapy given after removal of a cancerous tumor to further help in treatment. Many chemotherapy drugs are most effective after the majority of the tumor has been removed.