A misguided reaction to foreign substances by the immune system, the body system of defense against foreign invaders, particularly pathogens (the agents of infection). The allergic reaction is misguided in that these foreign substances are usually harmless. The substances that trigger allergy are called allergen. Examples include pollens, dust mite, molds, danders, and certain foods. People prone to allergies are said to be allergic or atopic.
Although allergies can develop at any age, the risk of developing allergies is genetic. It is related to ones family history of allergy. If neither parent is allergic, the chance for allergies is about 15%. If one parent is allergic, the risk increases to 30% and if both are allergic, the risk is greater than 60%.
Allergens cause the production of immunoglobulin E (IgE), an antibody that all of us have in small amounts. Allergic persons, however, produce IgE in abnormally quantities. Normally, this antibody is important in protecting us from parasites, but not from other allergens. During the sensitization period in allergy, IgE is overproduced. It coats certain potentially explosive cells that contain chemicals including histamine. These chemicals, in turn, cause inflammation and the typical allergic symptoms. This is how the immune system becomes misguided and primed to cause an allergic reaction when stimulated by an allergen.
The most common allergic conditions include hay fever (allergic rhinitis), asthma, allergic eyes (allergic conjunctivitis), allergic eczema, hives (urticaria), and allergic shock (also called anaphylaxis and anaphylactic shock). For a thumbnail sketch of each of these conditions:
Hay fever (allergic rhinitis) is the most common of the allergic diseases and refers to seasonal nasal symptoms that are due to pollens. Year round or perennial allergic rhinitis is usually due to indoor allergens, such as dust mites or molds. Symptoms result from the inflammation of the tissues that line the inside of the nose (mucus lining or membranes) after allergens are inhaled. Adjacent areas, such as the ears, sinuses, and throat can also be involved. The most common symptoms include:
Nasal itching (rubbing)
Itchy ears and throat
Post nasal drip (throat clearing)
Asthma is a breathing problem that results from the inflammation and spasm of the lung’s air passages (bronchial tubes). The inflammation causes a narrowing of the air passages, which limits the flow of air into and out of the lungs. Asthma is most often, but not always, related to allergies. Common symptoms include:
Shortness of breath
Allergic eyes (allergic conjunctivitis) is inflammation of the tissue layers (membranes) that cover the surface of the eyeball and the undersurface of the eyelid. The inflammation occurs a result of an allergic reaction and features:
Redness under the lids and of the eye overall
Watery, itchy eyes
Swelling of the membranes
Allergic eczema is an allergic rash that is usually not caused by skin contact with an allergen and features the following symptoms:
Itching, redness, and or dryness of the skin
Rash on the face, especially children
Rash around the eyes, in the elbow creases, and behind the knees, especially in adults
Hives (urticaria) are skin reactions that appear as itchy swellings and can occur on any part of the body. Hives can be caused by an allergic reaction, such as to a food or medication, but they also may occur in non-allergic people. Typical hive symptoms are:
Raised red welts
Allergic shock (anaphylaxis or anaphylactic shock) is a life-threatening reaction that can affect a number of organs at the same time. It typically occurs when the allergen is eaten (for example, foods) or injected (for example, a bee sting). Allergic shock is caused by dilated and “leaky” blood vessels, which result in a drop in blood pressure. Some or all of the following symptoms may occur:
Hives or reddish discoloration of the skin
Swelling of the throat
Stomach pain, nausea, vomiting
Shortness of breath, wheezing
Low blood pressure or shock
- Allergy and Infectious Diseases, National Inst.
Allergy & Infectious Diseases, National Institute of: One of the U.S. National Institutes of Health (NIH), the mission of the NIAID is “to support and conduct research and research training (that) strives to understand, treat, and ultimately prevent the myriad infectious, immunologic, and allergic diseases that threaten millions of human lives.” Immunology figures into this […]
- Allergy desensitization
Allergy desensitization: Stimulation of the immune system with gradually increasing doses of the substances to which a person is allergic in order to modify or stop the allergic response. This form of treatment is very effective for allergies to pollen, mites, animal dander, and stinging insects, including bees, hornets, yellow jackets, wasps, velvet ants, fire […]
- Allergy immunotherapy
Allergy immunotherapy: Stimulation of the immune system with gradually increasing doses of the substances to which a person is allergic. The aim is to modify or stop the allergy by reducing the strength of the IgE response. This form of treatment is very effective for allergies to pollen, mites, animal dander, and especially stinging insects. […]
- Allergy scratch test
Allergy scratch test: A test in which a small drop of the suspected allergy-provoking substance (allergen) is placed on the skin and the skin is then gently scratched through the drop with a sterile needle. If the skin reddens and, more importantly, if it swells, the test is read as positive, and allergy to that […]
- Allergy shots
See Allergy desensitization.