Blood clots, estrogen-associated

Blood clots, estrogen-associated: Blood clots are occasional but serious side effects of estrogen therapy. They are dose-related, that is, they occur more frequently with higher doses of estrogen.

Estrogen therapy preparations (all of which carry this risk) include:

esterified estrogens
esterified estrogens and methyltestosterone
estrogens (conjugated) and medroxyprogesterone
estrogens conjugated

The brand names of the estrogen therapy preparations carrying this risk include:

CLIMARA (estradiol)
ESTRACE (estradiol)
ESTRADERM (estradiol)
ESTRATAB (esterified estrogens)
ESTRATEST (esterified estrogens and methyltestosterone)
MENEST (esterified estrogens)
OGEN (estropipate)
PREMARIN (estrogens conjugated)
PREMPHASE (estrogens conjugated and medroxyprogesterone)
PREMPRO (estrogens conjugated and medroxyprogesterone)

Cigarette smokers on estrogen therapy are at a higher risk than non-smokers for blood clots. Therefore, patients requiring estrogen therapy are strongly encouraged to quit smoking.

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