BRCA2: A gene that normally acts to restrain the growth of cells in the breast and ovary but which, when mutated, may predispose to breast cancer and to ovarian cancer. BRCA2 mutations have also been discovered to be responsible for a significant fraction of early-onset prostate cancer. The first breast cancer genes identified were BRCA1 and BRCA2. Mutations of BRCA1 and BRCA2 account for about half of all cases of inherited breast cancer. These tumors tend to occur in young women. BRCA1 and BRCA2 are usually not involved in breast cancer that is not hereditary.
BRCA2 may regulate the fidelity of cytokinesis, the process by which two daughter cells separate at the completion of cell division. BRCA2 deficiency causes delays in cytokinesis and an increase in the frequency of binucleate cells, a consequence of defective cytokinesis. This role of BRCA2 in daughter cell separation may help to explain why BRCA2 tumor cells often contain alterations in chromosome number (aneuploidy), as well as structurally aberrant chromosomes.
- Breakbone Fever Medical Definition
Breakbone fever: Also known as dengue fever, an acute mosquito-borne viral illness of sudden onset that usually follows a benign course with headache, fever, prostration, severe joint and muscle pain, swollen glands (lymphadenopathy) and rash. The presence (the “dengue triad”) of fever, rash, and headache (and other pains) is particularly characteristic. Better known as dengue, […]
The breast refers to the front of the chest or, more specifically, to the mammary gland. The mammary gland is a milk producing gland. It is composed largely of fat. Within the mammary gland is a complex network of branching ducts. These ducts exit from sac-like structures called lobules, which can produce milk in females. […]
- Breast abscess
Breast abscess: A local accumulation of pus within the breast due to infection. Symptoms may include painful local swelling of the breast, a breast lump, and redness and tenderness of the breast. If the abscess forms in spite of antibiotics, it may need to be incised and drained, a minor surgical procedure, in order to […]
- Breast absence
Breast absence: A rare condition wherein the normal growth of the breast or nipple never takes place. They are congenitally absent. There is no sign whatsoever of the breast tissue, areola or nipple. There is nothing there. Absence of the breast (also called, amastia) is frequently not alone as the only problem. Unilateral amastia (amastia […]
- Breast aplasia
Breast aplasia: A rare condition wherein the normal growth of the breast or nipple never takes place. They are congenitally absent. There is no sign whatsoever of the breast tissue, areola or nipple. There is nothing there. Breast aplasia (also called, amastia) is frequently not alone as the only problem. Unilateral amastia (amastia just on […]