Bruton agammaglobulinemia tyrosine kinase: A genetic type of immunodeficiency characterized by failure to produce mature B lymphocytes and gamma globulin, due to mutation (change) in the agammaglobulinemia tyrosine kinase gene situated on the X chromosome (in the region Xq21.3-q22). The disorder is inherited as an X-linked recessive trait.
Patients are males with absent or minimal lymphoid tissue (for example, with little or no tonsils and adenoids) who are particularly prone to bacterial but not viral infections. Although patients have recurrent bacterial infections, they generally have a normal response to viral infection, because cell-mediated immunity is intact.
A notable exception is the usually fatal echovirus-induced meningoencephalitis often associated with a “dermatomyositis-like” syndrome. A clinical picture resembling rheumatoid arthritis develops in many patients.
Before the advent of antibiotics, death usually occurred in the first decade. Treatment today is with regular IV gamma globulin and prophylactic and therapeutic antibiotics. The prognosis is now markedly improved.
Grinding and gnashing of the teeth. Bruxism is due to clenching of the teeth other than in chewing and is associated with forceful lateral or protrusive jaw movements. This results in the grinding or rubbing together of the teeth. Bruxism can injure teeth and cause local pain in the mouth or jaw and may contribute […]
BP: Commonly used abbreviation for blood pressure. On a medical chart, you might see “BP90/60 T98.6 Ht60/reg R15,” which signifies that the blood pressure (BP) is 90/60 mm Hg, the temperature (T) is 98.6° Fahrenheit, the heart rate (Ht) is 60 beats per minute and regular, and respirations are occurring at 15 per minute.
bp: In genetics, base pair. In general medicine, blood pressure (but usually in capital letters as BP).
BSL-2: Biosafety level 2. A level of biosafety considered appropriate for agents that can cause human disease, but whose potential for transmission is limited.
BSL-3: Biosafety level 3. A level of biosafety considered appropriate for agents that may be transmitted by the respiratory route which can cause serious infection.