Chromosome 5q- syndrome
Chromosome 5q- syndrome: A blood disorder due to the loss of part of the long (q) arm of chromosome 5 in myeloid (bone marrow) cells, causing refractory (treatment-resistant) anemia, and myelodysplastic syndrome that is generally associated with a good prognosis but on occasion may lead to acute myeloid leukemia (AML). The immune modulating lenalidomide (Revlimid) is beneficial in male patients with the 5Q- syndrome and may reduce transfusion needs. It does lower white blood cells and platelet counts and is not a curative option.
Read Also:
- Chromosome band
Chromosome band: One of the transverse bands produced on chromosomes by differential staining techniques. Depending on the particular staining technique, the bands are alternating light and dark or fluorescent and nonfluorescent. Each human chromosome has a short arm (“p” for “petit”) and long arm (“q” for “queue”) separated by a centromere. The ends of the […]
- Chromosome banding
Chromosome banding: The treatment of chromosomes to reveal characteristic patterns of horizontal bands like bar codes. The banding patterns lend each chromosome a distinctive appearance so the 22 pairs of human nonsex chromosomes and the X and Y chromosomes can be identified and distinguished without ambiguity. Banding also permits the recognition of chromosome deletions (lost […]
- Chromosome complement
Chromosome complement: The whole set of chromosomes for a species. In humans, the normal chromosome complement consists of 46 chromosomes, including the 2 sex chromosomes. Also known as the karyotype.
- Chromosome disorder
Chromosome disorder: An abnormal condition due to something unusual in an individual’s chromosomes. For example, Down syndrome is a chromosome disorder caused by the presence of an extra copy of chromosome 21, and Turner syndrome is most often due to the presence of only a single sex chromosome: one X chromosome.
- Chromosome duplication
Chromosome duplication: Part of a chromosome in duplicate. A particular kind of mutation involving the production of one or more copies of any piece of DNA, including sometimes a gene or even an entire chromosome. A duplication is the opposite of a deletion. Duplications have been important in the evolution of the human genome (and […]