Cushingoid: Having the constellation of symptoms and signs caused by an excess of cortisol hormone: that is, Cushing syndrome.
While facial puffiness and weight gain are typical features of a Cushingoid appearance, cushing syndrome is an extremely complex hormonal condition that involves many areas of the body. Common symptoms are thinning of the skin, weakness, weight gain, bruising, hypertension, diabetes, thin weak bones (osteoporosis), facial puffiness and, in women, cessation of menstrual periods.
One of the commonest causes of Cushing syndrome is the administration of “cortisol-like medications” for the treatment of diverse diseases. All other cases of Cushing syndrome are due to the excess production of cortisol by the adrenal gland as, for example, due to:
An abnormal growth of the pituitary gland, which can stimulate the adrenal gland;
A benign or malignant growth within the adrenal gland itself, which produces cortisol; or
Production within another part of the body (ectopic production) of a hormone that directly or indirectly stimulates the adrenal gland to make cortisol.
The neurosurgeon Harvey Cushing (1869-1939) described excessive production of cortisol by the adrenal gland due specifically to an ACTH-secreting pituitary adenoma, a benign pituitary tumor that puts out ACTH (AdrenoCorticoTropic Hormone). This drives the adrenal gland to overproduce cortisol.
Cusp: In reference to heart valves, one of the triangular segments of the valve which opens and closes with the flow of blood. In reference to teeth, a raised area of the biting surface.
Cut: An area of severed skin. It is important to wash a cut with soap and water, and keep it clean and dry, but avoid putting alcohol, hydrogen peroxide, or iodine into a cut, which can delay healing. Delay in getting medical care can increase the rate of wound infection. If a cut results from […]
- Cutaneous allodynia
Cutaneous allodynia: Pain resulting from an innocuous stimulus to normal skin or scalp. The stimulus that triggers allodynia is not normally painful. The pain can be provoked by combing or brushing the hair, shaving, showering, wearing glasses or earrings. The pressure of a single strand of hair reportedly can feel like a jab with a […]
- Cutaneous papilloma
Cutaneous papilloma: A small tag of skin that may have a stalk (a peduncle). Cutaneous papillomas may appear on the skin almost anywhere although the favorite locales are the eyelids, neck, armpits (axillae), upper chest, and groin. Invariably benign, this tiny tumor of the skin usually causes no symptoms unless repeatedly irritated as, for example, […]
- Cutaneous syndactyly
Cutaneous syndactyly: A condition in which fingers or toes are joined together and the joining involves only the skin, not the bones.