Deficiency, LCHAD: Acute fatty liver of pregnancy (AFLP) has been found to be associated in some cases with an abnormality of fatty-acid metabolism. This abnormality is a deficiency of the enzyme long-chain-3-hydroxyacyl-CoA dehydrogenease (LCHAD).
The mother (and father) have 50% of normal LCHAD activity and the fetus has no LCHAD activity.
The metabolic disease in the baby’s liver apparently causes the fatty liver disease in the mother. In cases of AFLP due to LCHAD deficiency, there is a 25% (or greater) risk of AFLP in each pregnancy.
- Deficiency, magnesium
Deficiency, magnesium: Lack of magnesium, which can occur because of inadequate intake or impaired intestinal absorption of magnesium. Low magnesium levels are often associated with low calcium and potassium levels because these nutrients interact with each other. Magnesium deficiency causes increased irritability of the nervous system, as evidenced by spasms of the hands and feet, […]
- Deficiency, phenylalanine hydroxylase
Deficiency, phenylalanine hydroxylase: See Phenylalanine hydroxylase deficiency.
- Deficiency, protein C
Deficiency, protein C: Protein C is a protein in plasma that enters into the cascade of biochemical events leading to the formation of a clot. Deficiency of protein C results in thrombotic (clotting) disease.
- Deficiency, selenium
Deficiency, selenium: Lack of the essential mineral selenium, which can cause Keshan disease, a fatal form of disease of the heart muscle (cardiomyopathy) that was first observed in Keshan province in China and has since been found elsewhere. Treatment involves ensuring intake of the recommended dietary allowance of selenium, currently 70 mg per day for […]
- Deficiency, sphingomyelinase
Deficiency, sphingomyelinase: Also called Niemann-Pick disease, this is a disorder of the metabolism of a lipid (fat) called sphingomyelin that usually causes the progressive development of enlargement of the liver and spleen (hepatosplenomegaly), “swollen glands” (lymphadenopathy), anemia and mental and physical deterioration. Niemann-Pick disease is hereditary and follows an autosomal recessive pattern. The parents are […]