Disease, Kikuchi: A disorder that typically causes “swollen glands” in the neck (cervical lymphadeniopathy) together with fever or flu-like symptoms. Laboratory test abnormalities include elevated erythrocyte sedimentation rate (ESR), and white blood count abnormalities (low neutrophil count and elevated lymphocyte count with atypical lymphocytes in the peripheral blood).
Kikuchi disease is fairly common in young people, predominantly young women, in Asia. Also called Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis, this condition was discovered in Japan in 1972 and since then has seen in other areas of the world.
The overall picture is suggestive of a virus infection; autoimmune factors may also play a role. However, no infectious agent has yet been identified and autoimmunity remains hypothetical.
Diagnosis is based on characteristic pathologic findings on biopsy that differentiate this disease from others such as lymphoma, systemic lupus erythematosus, and infectious lymphadenopathies.
- Disease, Kimmelstiel-Wilson
Disease, Kimmelstiel-Wilson: Diabetic nephropathy (kidney disease). Kimmelstiel-Wilson disease is a kidney condition associated with long-standing diabetes. It affects the network of tiny blood vessels (the microvasculature) in the glomerulus, a key structure in the kidney that is composed of capillary blood vessels and which is critically necessary for the filtration of the blood. Features of […]
- Disease, kissing
Disease, kissing: Infectious mononucleosis (“mono”), a very common illness caused by the Epstein-Barr virus (EBV). By the time most people reach adulthood, an antibody against EBV can be detected in their blood meaning they have been infected with EBV. The illness is less severe in young children. The infection can be spread by saliva. Hence, […]
- Disease, Kok
Disease, Kok: A genetic disorder also known as hyperekplexia in which babies have an exaggerated startle reflex (reaction). This disorder was not recognized until 1962 when it was described by Drs. Kok and Bruyn as a disease with the onset at birth of hypertonia (stiffness), exaggerated startle response, strong brain-stem reflexes (especially head-retraction reflex) and, […]
- Disease, Kostmann
Disease, Kostmann: A condition with a lack of neutrophils (a type of white blood cell that is important in fighting infection). Children with this disease suffer frequent infections from bacteria which in the past led to death in three-quarters of cases before 3 years of age. This disease is also known as severe congenital neutropenia […]
- Disease, Legionnaire
Disease, Legionnaire: A disease due to the bacteria Legionella pneumophila found in plumbing, shower heads, water-storage tanks and air cooling systems. Outbreaks of Legionella pneumonia have been attributed to evaporative condensers and cooling towers. The bacteria thrives in the mist sprayed from air-conditioning ducts and so it can infest an entire building or airplane. Travelers […]