Donor lymphocyte infusion: (DLI) A cancer treatment in which lymphocytes from a bone marrow donor are infused into the person who received the original bone marrow transplant. The goal of donor lymphocyte infusion is to induce a remission of the cancer by a process called the graft-versus-tumor (GVT) effect. Donor lymphocyte infusion is basically meant to boost the GVT effect. The donor lymphocytes, which are T cells, attack and kill residual cancer cells. That is the strategy.
Donor lymphocyte infusion has mainly been used to treat relapsed chronic myelogenous leukemia (CML). Patients with relapsed acute leukemia, chronic lymphocytic leukemia (CLL), myelodysplasia (MDS), Hodgkin disease, non-Hodgkin lymphoma (NHL), and multiple myeloma have also been treated by donor leukocyte infusion.
- Donor, universal
Donor, universal: A person who is type O in the ABO blood group system and negative for the RhD blood group antigen and can donate blood to all recipients.
Dopa: A precursor (forerunner) of dopamine, a key neurotransmitter (messenger) in the brain. Dopa is used in the treatment of Parkinson disease. Parkinson disease is believed to be related to low levels of dopamine in certain parts of the brain. When dopa is taken by mouth, it crosses through the blood-brain barrier. Once it has […]
- Dopa-responsive dystonia (DRD)
Dopa-responsive dystonia (DRD): A condition that typically begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity and can be successfully treated with drugs. Segawa dystonia is an important variant of dopa-responsive dystonia. In Segawa dystonia, the symptoms fluctuate during the day from relative mobility in the morning to increasing […]
Dopamine: An important neurotransmitter (messenger) in the brain. Dopamine is classified as a catecholamine (a class of molecules that serve as neurotransmitters and hormones). It is a monoamine (a compound containing nitrogen formed from ammonia by replacement of one or more of the hydrogen atoms by hydrocarbon radicals). Dopamine is a precursor (forerunner) of adrenaline […]
- Doppler ultrasound
Doppler ultrasound: A form of ultrasound that can detect and measure blood flow. Doppler ultrasound depends on the Doppler effect, a change in the frequency of a wave resulting here from the motion of a reflector, the red blood cell. There are several kinds of Doppler ultrasound: Color Doppler — This technique estimates the average […]