Fibrous dysplasia, monostotic
Fibrous dysplasia, monostotic: Excessive growth in a single bone of hard-fibrous tissue that replaces the normal bone tissue. Symptoms of monostotic fibrous dysplasia may include pain and fracture of the bone. Most cases are diagnosed in adolescence or young adulthood and remain unchanged throughout life. The outlook is usually very good. Monostotic fibrous dysplasia appears to be a different disorder from polyostotic fibrous dysplasia.
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- Fibrous dysplasia, polyostotic
Fibrous dysplasia, polyostotic: A disorder that features the replacement of multiple areas of bone by fibrous tissue, which may cause fractures and deformity of the legs, arms, and skull. A genetic disorder that is characterized by polyostotic fibrous dysplasia along with skin pigmentation and hormonal problems, with premature sexual development, is known as McCune-Albright’s syndrome. […]
- Fibula
Fibula: The smaller of the two bones in the lower leg. The end of the fibula forms the bony prominence of the outer ankle.
- Fibulin 3
Fibulin 3: A protein that belongs to a family of extracellular proteins expressed in the basement membranes of blood vessels. The gene that encodes fibulin 3 is FBLN3 (or EFEMP1). FBLN3 is located on chromosome 2 in band 2p16. A single mutation in FBLN3 is responsible for an autosomal dominant form of macular degeneration. See […]
- Fibulin 5
Fibulin 5: A protein that belongs to a family of extracellular proteins expressed in the basement membranes of blood vessels. Fibulin 5 may be essential for the polymerization of elastin. Missense mutations in FBLN5, the gene that encodes fibulin 5, appear responsible for 1-2% of cases of age-related macular degeneration (AMD). FBLN5 is located on […]
- Field, visual
Field, visual: The entire area that can be seen when the eye is directed forward, including that which is seen with peripheral vision. The visual field can be tested to measure the extent and distribution of the field of vision. The test may be done by a number of methods including what are termed confrontation, […]