Fragile site
Fragile site: A point on a chromosome where gaps and breaks tend to occur, which can be passed on from one generation to another.
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- Fragile X chromosome
Fragile X chromosome: An X chromosome with a heritable fragile site associated with a frequent form of mental retardation — the fragile X syndrome. The fragile X chromosome was first sighted by Dr. Herbert A. Lubs in 1969 who termed it the “marker X.”. The fragile X is also called FRAXA. It was the first […]
- Fragile X syndrome
The most common heritable form of mental retardation. Fragile X syndrome is due to a dynamic mutation (a trinucleotide repeat) at an inherited fragile site on the X chromosome; therefore, it is an X-linked disorder. Characteristics of fragile X syndrome in boys may include, in addition to mental impairment, prominent or long ears, a long […]
- Fragile X tremor/ataxia syndrome
Fragile X tremor/ataxia syndrome: Abbreviated FXTAS (pronounced fax-tass). A progressive neurological disorder that strikes men over age 50 and causes tremor, ataxia (balance problems) and dementia that become increasingly severe with age. These men may be misdiagnosed with Parkinson’s or Alzheimer’s disease. The disorder is due to a small mutation (premutation) in the same gene […]
- Frailty syndrome
Frailty syndrome: A condition, seen particularly in older patients, characterized by low functional reserve, easy tiring, decrease of libido, mood disturbance, accelerated osteoporosis, decreased muscle strength, and high susceptibility to disease. People with the frailty syndrome may take a sudden turn for the worse and die. However, the frailty syndrome may sometimes be reversible.
- Frambesia
Frambesia: Also known as yaws, frambesia is a common chronic infectious disease that occurs mainly in the warm humid regions of the tropics with characteristic bumps on the skin of the face, hands, feet and genital area. Almost all cases of yaws are in children under 15 years of age. The organism that causes yaws […]