An inherited disorder characterized by abnormally high absorption of iron by the intestinal tract, resulting in excessive storage of iron, particularly in the liver, skin, pancreas, heart, joints, and testes. Common early symptoms include abdominal pain, weakness, lethargy, and weight loss. The onset of symptoms is usually between 30 to 50 years of age in males and after menopause in females. The excess iron gives the skin a bronze color and damages the liver, causing liver scarring (fibrosis) or cirrhosis, usually after age 40. Diabetes also occurs due to damage to the pancreas. Other findings include congestive heart failure or arrhythmias, arthritis, and hypogonadism. Treatment is removal of excess iron by periodic phlebotomy (removal of blood) to deplete the body iron. Early diagnosis and treatment before symptoms develop prevents all the complications of the disease. Hemochromatosis is inherited in an autosomal recessive manner. Also known as bronze diabetes and hereditary hemochromatosis.
A medical procedure to remove fluid and waste products from the blood and to correct electrolyte imbalances. This is accomplished using a machine and a dialyzer, also referred to as an “artificial kidney.” Hemodialysis is used to treat both acute (temporary) and chronic (permanent) kidney failure.
the iron in hemoglobin is salvaged, transported to the bone marrow by a protein called transferrin and used again in the production of new red blood cells; the remainder of the hemoglobin becomes a chemical called bilirubin that is excreted into the bile which is secreted into the intestine, where it gives the feces their […]
- Hemoglobin A
Normal adult hemoglobin, the main type of hemoglobin found after infancy. The A stands for adult.
- Hemoglobin A1C
The higher the glucose concentration in blood, the higher the level of HbA1c. Levels of HbA1c are not influenced by daily fluctuations in the blood glucose concentration but reflect the average glucose levels over the prior 6 to 8 weeks. Measurement of HbA1c is a useful indicator of how well the blood glucose level has […]
- Hemoglobin E
Normal embryonic hemoglobin, the main type of hemoglobin found in the human embryo. The E stands for embryonic and also for epsilon, a chain that is unique to embryonic hemoglobin. Originally known as Gower-2.