Interleukin-10
Abbreviated IL-10. An antiinflammatory and immunosuppressive substance produced within the body. IL-10 plays a role in the regulation of immune responses. It is secreted by antigen-presenting cells, promotes the development of immunologic tolerance, and suppresses the production of inflammatory cytokines. The gene for IL-10 is in chromosome region 1q31-q32.
IL-10 modulates acute graft-versus-host disease (GVHD), a major complication in bone marrow transplant. The presence of a particular variant in the recipient’s IL-10 gene is associated with a substantial decrease in the risk of GVHD. Knowledge of the recipient’s IL-10 genotype helps predict the chance of GVHD.
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- Interleukin-2
A type of interleukin, a chemical messenger, a substance that can improve the body’s response to disease. It stimulates the growth of certain disease-fighting blood cells in the immune system. Also called IL-2.
- Interleukin-3
A protein that stimulates the immune system to develop mast cells and bone-marrow cells. Abbreviated IL-3.
- Interleukin-4
A protein that stimulates the immune system to develop mast cells, resting T-cells, and activated B-cells. Abbreviated IL-4.
- Interleukins
Substances used in biological therapy. Interleukins stimulate the growth and activities of certain kinds of white blood cells.
- Intermediate-grade lymphoma
A lymphoma that is more aggressive (grows and spreads faster) than a low-grade lymphoma, but responds better to anticancer drugs. Intermediate-grade lymphomas include diffuse, small, cleaved cell lymphoma and diffuse, large, noncleaved cell lymphoma. Also called an aggressive lymphoma.