Knockout
Inactivation of specific genes. Knockouts are often created in laboratory organisms such as yeast or mice so that scientists can study the knockout organism as a model for a particular disease.
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- Knockout mouse
A mouse missing a single gene (that has been knocked out). Knockout mice are used in biomedical research.
- Knuckle
The top of the flexed finger joint.
- Koch's postulates
It has acquired extra virulence factors making it pathogenic. It gains access to deep tissues via trauma, surgery, an IV line, etc. It infects an immunocompromised patient. Not all people infected by a bacteria may develop disease-subclinical infection is usually more common than clinically obvious infection. Despite such limitations, Koch’s postulates are still a useful […]
- Kok disease
A genetic disorder also known as hyperexplexia in which babies have an exaggerated startle reflex (reaction). This disorder was not recognized until 1962 when it was described by Drs. Kok and Bruyn as a disease with the onset at birth of hypertonia (stiffness), exaggerated startle response, strong brain-stem reflexes (especially head-retraction reflex) and, in some […]
- Kostmann disease
severe congenital neutropenia (SCN). SCN was first clearly described by Kostmann in 1956. It is now known to be caused by a defect in a gene on chromosome 1 (in 1p35-p34.3) that codes for what is called the granulocyte colony-stimulating factor receptor (GCSFR). Treatment with recombinant human granulocyte colony-stimulating factor (GCSF) elevates the granulocyte counts, […]