A rare, inherited disorder characterized by degeneration of the central nervous system. Leigh’s disease can be caused by mutations in mitochondrial DNA or by deficiencies of an enzyme called pyruvate dehydrogenase. Symptoms usually begin between the ages of 3 months and 2 years and progress rapidly. Early symptoms may include poor sucking ability and loss of head control and motor skills, loss of appetite, vomiting, irritability, continuous crying, and seizures. As the symptoms progress, weakness, lack of muscle tone, and episodes of lactic acidosis, which can lead to impairment of respiratory and kidney function, may occur. The prognosis is poor.
A benign tumor of smooth muscle, the type of muscle that is found in the heart and uterus. A leiomyoma of the uterus is commonly called a fibroid. Uterine fibroids are the single most common indication for hysterectomy. Fibroids can be present and be inapparent. However, they are clinically apparent in up to 25% of […]
A malignant tumor that originates in smooth muscle, the major structural component of most hollow internal organs and the walls of blood vessels. Leiomyosarcoma can occur almost anywhere in the body but is most frequently found in the uterus and gastrointestinal tract. Complete surgical excision, if possible, is the treatment of choice.
- Leishmania infection
Mexico, Central America, and South America — from northern Argentina to southern Texas (not in Uruguay, Chile, or Canada) Southern Europe (leishmaniasis is not common in travelers to southern Europe) Asia (not Southeast Asia) The Middle East Africa (particularly East and North Africa, with some cases elsewhere) More than 90% of the world’s visceral leishmaniasis […]
A parasitic disease that is spread by the bite of sand flies infected with the protozoa Leishmania. There are several forms of leishmaniasis, the most common being cutaneous and visceral leishmaniasis (known as kala-azar). The cutaneous form of the disease causes skin sores and is usually named for a geographic place (for example, Jericho boil, […]
- Lemierre syndrome
A potentially lethal form of sore throat caused by the bacterium Fusobacterium necrophorum, a common inhabitant of the mouth. This disease vanished with the advent of antibiotics but then returned decades later. It has been called the “forgotten disease.” Lemierre syndrome develops most often after a strep sore throat has created a peritonsillar abscess, a […]