A disorder characterized by painless symmetrical diffuse deposits of fat beneath the skin of the neck, upper trunk, arms and legs.
The condition is thought to be genetic although its exact mode of inheritance is uncertain. It may be a mitochondrial DNA disease. It frequently appears in association with alcoholic liver disease, macrocytic anemia (“low blood” with big red blood cells) and peripheral neuropathy (disease of the peripheral nervous system, as opposed to the brain and spinal cord). The peripheral neuropathy has often been laid to alcoholism, but the neuropathy is likely an integral part of the syndrome.
This disorder affects mainly men and is more frequent in the Mediterranean area. It has been suggested that the distribution of fat in multiple symmetric lipomatosis resembles that of a pre-Roman (6th century BC) Italic statue called the Capestrano warrior discovered in the Abruzzi region of Italy.
Multiple symmetric lipomatosis is also known as cephalothoracic lipodystrophy, the Launois-Bensaude syndrome and Madelung disease. It was called ‘fat neck’ (Fetthals) by Madelung in 1888.
Peripheral neuropathy is when the peripheral nerves (as compared to the spinal cord or brain) become the source of pain. One way to look at pain is whether it is in response to an appropriate stimulus, such as someone stepping on your toe, or whether the pain occurs for no obvious reason; malfunctioning of the […]
A molecule that is a combination of lipid and protein. Lipids do not travel in the blood by themselves, but they are carried through the bloodstream as lipoproteins.
high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL). The first stages of cholesterol build up in the blood vessels (atherosclerosis) occur when LDL particles circulating in the blood penetrate through the inner lining of blood vessels and become trapped in the artery wall. Eventual build up of LDL, fat-filled cells, […]
A malignant tumor that arises in fat cells in deep soft tissue, such as that inside the thigh. Most frequent in middle-aged and older adults (age 40 and above), liposarcomas are the most common of all soft-tissue sarcomas.
The surgical suctioning of fat deposits from specific parts of the body, the most common being the abdomen, buttocks, hips, thighs and knees, chin, upper arms, back, and calves. A hollow instrument called a cannula is inserted under the skin to break up the fat. A high-pressure vacuum is then applied to the cannula to […]