Loss-of-function mutation
A mutation that results in reduced or abolished protein function. Gain-of-function mutations,which are much less common, confer an abnormal activity on a protein.
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Pain in the lower back area that can relate to problems with the lumbar spine, the discs between the vertebrae, the ligaments around the spine and discs, the spinal cord and nerves, muscles of the low back, internal organs of the pelvis and abdomen, or the skin covering the lumbar area.
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