A gene that is necessary and sufficient by itself to cause a condition. For example, the APC gene is a major gene for colorectal cancer.
- Major histocompatibility complex
Abbreviated MHC. A cluster of genes located on chromosome 6 concerned with antigen production and critical to the success of transplantation. The MHC includes the human leukocyte antigen (HLA) genes.
Poor intestinal absorption of nutrients. Malabsorption can occur from diseases that injure the bowels, such as Crohn’s disease, Whipple’s disease, celiac disease, and many others.
Softening. For example, osteomalacia is softening of bone, usually due to deficiency of calcium and vitamin D.
A vague feeling of discomfort, one that cannot be pinned down but is often sensed as ‘just not right.’
Referring to the cheek. For example, a malar rash is a rash that appears over the cheeks.