Nonpenetrant trait


A genetic trait (characteristic) that is present in the genome but does not manifest itself in the individual. By contrast, a penetrant trait is one that manifests itself.

If, for example, if 100 people have a particular genetic trait but only 80 of them express it, the penetrance of that trait is 80%. The trait is nonpenetrant in 20% of people who have it.

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    Not by chance alone. Not in keeping with the process by which an outcome is determined solely by chance, for example, by a coin flip. The opposite of nonrandom is random.

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  • Nonsense mutation

    A mutation (a change) in a base in the DNA that prematurely stops the translation (reading) of messenger RNA (mRNA) resulting in a polypeptide chain that ends prematurely and a protein product that is truncated (abbreviated) and incomplete and usually nonfunctional. The nonsense mutation converts a codon (a triplet of bases) that encodes an amino […]

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  • Nonsyndromic

    Not part of a syndrome. Hearing loss, for instance, can be syndromic or nonsyndromic.


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