Off-label use
In the United States, the regulations of the Food and Drug Administration (FDA) permit physicians to prescribe approved medications for other than their intended indications. This practice is known as off-label use.
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- Off-pump CABG
A coronary artery bypass graft (CABG) done without putting the patient on the heart-lung machine. Off-pump CABG permits surgery on multiple vessels within the heart by mechanically stabilizing it. Off-pump surgery is minimally invasive, as compared to surgery on the heart-lung machine. The potential benefits include shorter hospital stay, less bleeding, less chance for infection, […]
- Off-pump surgery
A technique for heart surgery designed to avoid use of the heart-lung machine. The technique permits surgery on multiple vessels within the heart by mechanically stabilizing it. Off-pump surgery is minimally invasive, as compared to surgery on the heart-lung machine. The potential benefits include shorter hospital stay, less bleeding, less chance for infection, less risk […]
- Office of Human Research Protections (OHRP)
The agency responsible for developing, monitoring and exercising compliance over the protections afforded human subjects in all research supported by the US Department of Health and Human Services (DHHS). Formerly called the Office for Protection from Research Risks (OPRR).
- Offspring
The progeny, or young, born to a person. In a larger sense, the offspring are collectively all the descendants, the brood, or the family. For example, the offspring of someone with a genetic (inherited) condition, such as Huntington?s disease, are themselves at risk for the disease.
- OGG1
A DNA repair enzyme with antimutator activity. OGG1 is one of a number of enzymes that repair damage done to DNA by environmental mutagens such as those in cigarette smoke. The gene for OGG1 is located on chromosome 3p25. Mutations in OGG1 were first reported in 1999. The OGG1 gene is polymorphic with multiple normal […]