Osteitis deformans
Arthritis — Long bones in the leg may bow, distorting alignment and increasing pressure on nearby joints. In addition, Pagetic bone may enlarge, causing joint surfaces to undergo excessive wear and tear. In these cases, pain may be due to a combination of Paget disease and osteoarthritis.
Hearing — Loss of hearing in one or both ears may occur when Paget disease affects the skull and the bone that surrounds the inner ear. Treating the Paget disease may slow or stop hearing loss. Hearing aids may also help.
Heart disease — In severe Paget disease, the heart works harder to pump blood to affected bones. This usually does not result in heart failure except in some people who also have hardening of the arteries.
Kidney stones — Kidney stones are somewhat more common in patients with Paget disease.
Nervous system — Pagetic bone can cause pressure on the brain, spinal cord, or nerves, and reduced blood flow to the brain and spinal cord.
Sarcoma — Rarely, Paget disease is associated with the development of osteosarcoma, a malignant tumor of bone. When there is a sudden onset or worsening of pain, sarcoma should be considered.
Teeth — When Paget disease affects the facial bones, the teeth may become loose. Disturbance in chewing may occur.
Vision–Rarely, when the skull is involved, the nerves to the eye may be affected, causing some loss of vision.
Paget disease is NOT associated specifically with osteoporosis. Although Paget disease and osteoporosis can occur in one and the same person, they are completely different disorders. But, despite their marked differences, many treatments for Paget disease can also be used to treat osteoporosis.
The goal of drug treatment is to control Paget disease activity for as long a period of time as possible. Treatment options include aspirin, other anti-inflammatory medications, pain medications, and medications that slow the rate of bone turnover, such as calcitonin (Calcimar, Miacalcin) and the bisphosphonates including etidronate (Didronel), alendronate (Fosamax), pamidronate (Aredia), tiludronate (Skelid), and risedronate (Actonel).
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A condition that is associated with excessive parathyroid hormone production (hyperparathyroidism), in which bone tissue becomes soft and deformed. Treatment is directed toward the underlying parathyroid condition and relieving any bone pain.
- Osteo- (prefix)
Combining form meaning bone. From the Greek “osteon”, bone. Appears for instance in osteoarthritis, osteochondroma osteodystrophy, osteogenesis, osteomyelitis, osteopathy, osteopetrosis, osteoporosis, osteosarcoma, etc.
- Osteoarthritis
A type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis.
- Osteoarthropathy
Any disease of the bones and joints. From osteo-, bone + -arthro-, joint, + pathy, disease.
- Osteoblast
A cell that makes bone. It does so by producing a matrix that then becomes mineralized. Bone mass is maintained by a balance between the activity of osteoblasts that form bone and other cells called osteoclasts that break it down.