Ulcerative colitis that is limited to the rectum. Ulcerative colitis itself is a relatively common disease involving inflammation of the large intestine (the colon). The cause is unknown. It is a form of inflammatory bowel disease and has some similarity to a related disorder, Crohn’s disease.
The end of the colon (the rectum) is always involved in ulcerative colitis. When the inflammation is limited to the rectum, as mentioned, it is called ulcerative proctitis. In ulcerative colitis, the inflammation may extend into the upper parts of the colon. When the entire colon is involved, the terms pancolitis or universal colitis are used.
The symptoms of ulcerative colitis include crampy abdominal pain, diarrhea, and intermittent rectal bleeding. Ulcerative colitis characteristically waxes and wanes. Many patients experience long remissions, even without medication. Ulcerative colitis may mysteriously resolve (“burn out”) after a long history of symptoms.
Direct visualization (proctosigmoidoscopy or colonoscopy) with sampling of the lining of the bowel is the most accurate diagnostic test. Especially in new cases, infections and other diseases that can mimic ulcerative colitis have to be considered and excluded.
Long-standing ulcerative colitis increases the risk for colon cancer. Ulcerative colitis can also be associated with inflammation in joints, spine, skin, eyes, the liver and its bile ducts.
The treatment of ulcerative colitis involves medications and/or surgery. Since inflammatory bowel disease is currently an area of active and productive research, new treatments are anticipated which, it is hoped, will be of value in ulcerative colitis.
A medical specialty that deals with disorders of the rectum and anus.
An examination of the rectum and the lower part of the colon, using a thin, lighted instrument called a sigmoidoscope.
A precursor (forerunner) of a drug. A prodrug must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent. For example, sulfasalazine is a prodrug. It is not active in its ingested form. It has to be broken down by bacteria in the colon into two products — 5-aminosalicylic acid (5ASA) and sulfapyridine […]
- Product, gene
The RNA or protein that results from the expression of a gene. The amount of gene product is a measure of the degree of gene activity.
Emery-Dreifuss muscular dystrophy type 2, limb girdle muscular dystrophy type 1B, Charcot-Marie-Tooth disorder type 2B1, the Dunnigan type of familial partial lipodystrophy, mandibuloacral dysplasia and a familial form of dilated cardiomyopathy. There currently are no diagnostic tests or treatments for progeria which remains relentlessly progressive and fatal. Although Hutchinson (1886) and Guilford (1904) did describe […]