A progressive disease of the nervous system characterized by spasticity (tightness), myoclonus and dementia and by liver problems with jaundice and cirrhosis. This disorder, first described by Alpers in 1931 as “Diffuse progressive degeneration of gray matter of cerebrum”, usually begins early in life with convulsions. A continuous seizure (status epilepticus) is often the final event.
Alpers progressive infantile poliodystrophy is due to more than one cause. Some cases are inherited as autosomal recessive traits with both parents appearing normal but carrying one Alpers gene and each of their children, boys and girls alike, running a 1 in 4 risk of receiving both of the parental Alpers genes and suffering from this dread disease.
Other cases of Alpers disease are due to disorders of oxidative phosphorylation, including mitochondrial DNA depletion syndromes. (Phosphorylation is the addition of phosphate to an organic compound, such as the addition of phosphate to ADP [adenosine diphosphate] to form ATP [adenosine triphosphate] or the addition of phosphate to glucose to produce glucose monophosphate, through the action of enzymes known as phosphotransferases or kinases.)
Also called Alpers disease, diffuse degeneration of cerebral gray matter with hepatic cirrhosis and Alpers diffuse degeneration of cerebral gray matter with hepatic cirrhosis.
- Progressive multifocal leukoencephalopathy
A rapidly progressive, often fatal viral infection of the brain. Commonly abbreviated as PML. PML is believed to be due to the Jacob-Creutzfeldt (JC) papovavirus. The virus infects oligodendrocytes (support cells in the brain). The signs and symptoms of PML include headaches, memory loss, changes in mental status, speech and vision difficulties, loss of strength, […]
- Progressive supranuclear palsy
A neurologic disorder of unknown origin that gradually destroys cells in many areas of the brain, leading to serious and permanent problems with the control of gait and balance. The most obvious sign of the disease is an inability to aim the eyes properly, which occurs because of damage in the area of the brain […]
- Progressive vaccinia
A severe complication of smallpox vaccination that occurs because of an immune defect in the vaccinated individual or in a susceptible contact of that person. In progressive vaccinia, the primary vaccination site does not heal but rather expands with extensive necrosis (death of tissue), eventually covering large portions of body with extensive destruction of normal […]
Capable of promoting inflammation. For example, air pollution may have proinflammatory effects.
An organism whose cells lack a discrete nucleus and other special subcellular compartments. Bacteria and viruses are prokaryotes. Humans are not prokaryotes, but rather eukaryotes.