Representational oligonucleotide microarray analysis. A method for the detection of genomic aberrations between any two samples of DNA. ROMA measures the relative concentration of DNA in the two samples by hybridizing differentially labeled samples to a set of probes. By arraying oligonucleotide probes designed from the human genome sequence, and hybridizing with “representations” from the two genomes, regions of the genome with altered “copy number” can be detected. ROMA has permitted the identification of variation between cancer and normal genomes, as well as between normal human genomes.
Large-scale variations have been found in the normal genome from one person to the next. These large variations are termed copy number polymorphisms (CNPs). They are common and are widely distributed in the human genome. In an analysis of 20 individuals from different geographic backgrounds, this type of large genomic variation occurred at least once in every 70 genes. ROMA has revealed that there is considerable variation in the human genome, most of which was not even suspected by other methods of genomic analysis.
- Rooting reflex
A reflex that is seen in normal newborn babies, who automatically turn the face toward the stimulus and make sucking (rooting) motions with the mouth when the cheek or lip is touched. The rooting reflex helps to ensure successful breastfeeding.
- Rorschach test
A common psychological test that involves using inkblots that show enigmatic and highly ambiguous shapes. Ten standardized blots are shown, one at a time, to a person, and the person’s responses are recorded, to determine what the person perceives about the inkblots.
mainly the forehead, the chin, and the lower half of the nose. The tiny blood vessels in these areas enlarge (dilate) and become more visible through the skin, appearing like tiny red lines (telangiectasias). Pimples that look like teenage acne can occur. Rosacea occurs most often between the ages of 30 and 60, especially in […]
- Rosacea keratitis
A condition affecting the eyes in about half of all cases of rosacea. It is characterized by burning and grittiness of the eyes (conjunctivitis). If this is not treated, inflammation of the cornea may impair vision.
A child with rash and no fever may usually return to child care. Because the rash appears so suddenly (right after the fever dramatically departs), the disease is also sometimes called exanthem subitum.