SIDDT
Sudden infant death with dysgenesis of testes.
SIDDT is an autosomal recessive syndrome that was first identified in an Old Order Amish community in Pennsylvania. Over two generations, nine families from this community had lost 21 infants to sudden death. All infants with SIDDT died before 12 months of age of abrupt cardiac and respiratory arrest. Males with SIDDT may also have underdeveloped testes. Females appear to be normal. Male and female infants with SIDDT died suddenly at the same age.
The gene responsible for SIDDT is on chromosome 6. The gene called TSPYL is expressed both in the brainstem and in testes. DNA sequencing of the gene in four children with SIDDT revealed mutations in TSPYL. All affected infants had two abnormal copies of the TSPYL gene and all parents were carriers of one copy of the mutant TSPYL gene.
Read Also:
- Side effects
Problems that occur when treatment goes beyond the desired effect. Or problems that occur in addition to the desired therapeutic effect. Example — A hemorrhage from the use of too much anticoagulant (such as heparin) is a side effect caused by treatment going beyond the desired effect. Example — The common side effects of cancer […]
- SIDS (sudden infant death syndrome)
The sudden and unexpected death of a baby with no known illness, typically affecting sleeping infants between the ages of two weeks to six months. Infants with a brother or sister who died of SIDS; babies whose mothers used heroin, methadone, or cocaine during pregnancy; infants born weighing less than 4.4 pounds; children with an […]
- Sight, day
Night blindness. Listed in medical dictionaries under “Nyctalopia” from the Greek “nyct’ (night) + “aloas” (obscure or blind) + “opsis” (vision), the condition involves impaired vision in dim light and in the dark (but normal sight in bright light), due to impaired function of specific vision cells (the “rods”) in the retina. Day sight (night […]
- Sigma Theta Tau
The international honor society for nursing. Membership is by invitation to baccalaureate and graduate nursing students, who demonstrate excellence in scholarship, and to community leaders exhibiting exceptional achievements in nursing. More than a quarter million nurse scholars have been inducted into Sigma Theta Tau. Sixty percent of the currently active 120,000 members in Sigma Theta […]
- Sigmoid
In human anatomy, the lower colon (the lower portion of the large bowel). Sigmoid is short for sigmoid colon. From the Greek letter sigma, which is shaped like a C. Sigmoid also means curved in two directions like the letter S. For example, a sigmoid curve is an S-shaped curve.