Sulfa drug


One of the sulfonamides, the sulfa-related antibiotics which are used to treat bacterial and some fungal infections.

The first sulfa drug was prontosil. It was discovered by the German physician and chemist Gerhard Domagk in 1935.

Sulfa drugs kill bacteria and fungi by interfering with their metabolism. They were the “wonder drugs” before penicillin and are still used today. Because sulfa drugs concentrate in the urine before being excreted, treating urinary tract infections is one of their most common uses. Sulfa drugs can have a number of interactions with prescription and over-the-counter drugs (including PABA sunscreens), and are not appropriate for people with some health conditions.

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  • Sulfite sensitivity

    Adverse reactions of an allergic nature to sulfites. Sulfites occur in fermentation and also occur naturally in a number of foods and beverages including wine. Sulfites are used for their preservative properties. Sulfite sensitivity occurs most often in asthmatic adults — predominantly women. It is uncommon in preschool children. Adverse reactions to sulfites in nonasthmatics […]

  • Sulfonamides

    Thiosulfil Forte), sulfamethoxazole (Gantanol), sulfasalazine (Azulfidine), sulfisoxazole (Gantrisin), and various high-strength combinations of three sulfonamides. Sulfa drugs kill bacteria and fungi by interfering with cell metabolism. They were the wonder drugs before penicillin and are still used today. Because sulfa drugs concentrate in the urine before being excreted, treating urinary tract infections is one of […]

  • Sulfonylurea

    A class of oral hypoglycemic agents (medications that lower the level of blood glucose) taken by people with type 2 diabetes. The sulfonylureas increase the secretion of insulin by the pancreas. There are two generations of sulfonylureas. The main difference between the first- and second-generation sulfonylureas is in the way they are ‘eliminated from the […]

  • Sulfonylurea sensitivity

    Sensitivity to the hypoglycemic effects of the oral hypoglycemic agents in the sulfonylurea class.

  • Sulphonylurea

    Alternate spelling (preferred in the U.K.) of sulfonylurea.


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