One of a family of core proteins with sugars attached to the cell surfaces that control or influence tissue repair, metabolism, the formation of tumors and the development of immune responses. The name is derived from the Greek syndein, to bind together.
There are 4 known members of the syndecan family. All are proteoglycans (molecules composed of protein and glycosaminoglycans, a type of polysaccharide). The syndecans are ubiquitous components of the plasma membranes of cells, act as receptors for the extracellular matrix, and are involved in intracellular communication.
The gene SDC1 for syndecan-1 is on chromosome 2p24.1. The gene SDC2 for syndecan-2 is on chromosome 8q22-q24. The gene SDC3 for syndecan-3 has not yet been mapped to a specific chromosome location. The gene SDC4 for syndecan-4 is on chromosome 20q12-q13.
A set of linked health problems involving two or more afflictions, interacting synergistically, and contributing to excess burden of disease in a population. Syndemics occur when health-related problems cluster by person, place, or time. For example, the SAVA syndemic is comprised of substance abuse, violence, and AIDS, three conditions that disproportionately afflict those living in […]
- Syndromatic hepatic ductular hypoplasia
Also called Alagille syndrome or arteriohepatic dysplasia, this is a genetic disorder characterized by jaundice in the newborn period, liver disease with cholestasis, peripheral pulmonic stenosis and unusual face. Children with Alagille syndrome usually present with jaundice (yellowing of the skin and whites of the eyes) in the newborn period. Stagnant flow of bile from […]
A combination of symptoms and signs that together represent a disease process.
- Syndrome of ichthyosis, spasticity, oligophrenia
NAD+ oxidoreductase deficiency (FAO deficiency); fatty aldehyde dehydrogenase deficiency (FALDH deficiency); and fatty aldehyde dehydrogenase 10 deficiency (FALDH10 deficiency).
- Syndrome, abdominal muscle deficiency
Abdominal muscle deficiency syndrome.