Syndrome, Danlos
50. A son with the gene is affected with the disease while a daughter with the gene is merely a carrier like her mother.
Type VI EDS (the ocular-scoliotic form of EDS) is characterized by a fragile globe of the eyes, significant skin and joint laxity, and severe curvature of the spine (scoliosis). It is inherited as an autosomal (non-sex- linked) recessive genetic trait. Recessive means that two copies of the gene are required to produce the disease.
Type VII EDS (arthrochalasis multiplex congenita). Patients with this type of EDS are short in height and severely affected by joint laxity and dislocations. Skin involvement is variable. Autosomal dominant and recessive inheritance is possible.
Type VIII EDS. Patients have different degrees of joint hypermobility and inflammation of the gums and bone adjacent to the teeth (periodontitis).
Type IX EDS. Patients have mildly hypermobile joints and can have mitral valve prolapse. It is inherited as autosomal dominant.
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50 chance of transmitting it to a son who then will suffer from the disease. The average age at death is 24 years.