A chronic form of gout. Nodular masses of uric acid crystals (tophi) are deposited in different soft tissue areas of the body. Even though tophi are most commonly found as hard nodules around the fingers, at the tips of the elbows, and around the big toe, tophi nodules can appear anywhere in the body. They have been reported in unexpected areas such as in the ears, vocal cords, or even against the spinal cord!
A nodular mass of uric acid crystals. Tophi are characteristically deposited in different soft tissue areas of the body in chronic (tophaceous) gout. Even though tophi are most commonly found as hard nodules around the fingers, at the tips of the elbows, and around the big toe, they can appear anywhere in the body. They […]
Pertaining to a particular surface area. For example, a topical agent is applied to a certain area of the skin and is intended to affect only the area to which it is applied. Whether its effects are indeed limited to that area depends on whether the agent stays where it is put or is absorbed […]
- Topical chemotherapy
Treatment with an anticancer drug in a lotion, ointment or cream that is applied to the skin.
A class of enzymes that alter the supercoiling of double-stranded DNA. (In supercoiling the DNA molecule coils up like a telephone cord, which shortens the molecule.) The topoisomerases act by transiently cutting one or both strands of the DNA. Topoisomerase type I cuts one strand whereas topoisomerase type II cuts both strands of the DNA […]
- TORCH screen
A blood test that is designed to screen for a group of infectious agents known by the acronym TORCH, which stands for Toxoplasma gondii, other viruses (HIV, measles, and so on), rubella (German measles), cytomegalovirus, and herpes simplex. All these infectious agents are teratogens (agents that are capable of causing birth defects). The TORCH infectious […]