Transplantation genetics
class I (HLA-A,B,Cw), class II (HLA-DR,DQ,DP) and class III (no HLA genes).
The need for HLA matching depends on the type of transplant. In bone marrow transplantation, HLA matching is an absolute necessity, lest the cells be rejected. In corneal transplantation, HLA matching is less relevant because of the lack of blood vessels in the cornea and the “immunological privilege” of the cornea. HLA matching is not crucial but is beneficial to the success of most solid organ transplantation including kidney, liver, heart, lung, pancreas, and intestine.
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