Trimethylaminuria (TMA)

An inborn error of metabolism associated with an offensive body odor, the smell of rotting fish, due to the excessive excretion of TMA in urine, sweat, and breath. Persons with TMA may experience tachycardia (fast heart rate) and severe hypertension (high blood pressure) after eating cheese (which contains tyramine) and after using nasal sprays containing epinephrine. TMA is caused by a mutation (change) in the gene for an enzyme, flavin-containing monooxygenase-3 (FMO3) encoded by a gene on chromosome #1. The FMO3 enzyme metabolizes tyramine (which is in cheese). The syndrome is associated with various psychosocial reactions, including social isolation, clinical depression and attempted suicide.

Read Also:

  • Trinucleotide

    A sequence of 3 base pairs; a triplet of bases. The gene code is made up of trinucleotides.

  • Trip

    Street name for alpha-ethyltryptamine and for LSD.

  • Tripeptide

    A peptide consisting of three amino acids.

  • Triphalangeal

    Having three phalanges in a digit normally composed of only two.

  • Triple C's

    Street name for dextromethorphan (DXM).

Disclaimer: Trimethylaminuria (TMA) definition / meaning should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. All content on this website is for informational purposes only.