A class of drugs introduced in the 1990s for the treatment of migraine that act as agonists for 5-hydroxytryptamine (5-HT) receptors. The triptans are often very effective in relieving migraine but do not prevent future attacks or lessen their frequency.
Migraine is believed to be due to dilatation of cranial blood vessels and the release of pro-inflammatory neuropeptides through nerve endings in the trigeminal nerve system.
The antimigraine activity of the triptans likely lies in their agonist effects on the 5-HT receptors in the intracranial blood vessels and nerves of the trigeminal system which result in cranial vessel constriction and inhibition of pro-inflammatory neuropeptide release.
The presence or absence of skin sensitivity (cutaneous allodynia) reportedly helps predict how a person with migraine will respond to a triptan. For most migraine patients without skin sensitivity, triptans work, regardless of when they take the drug. But in migraineurs with skin sensitivity, the triptans work best when taken early, within 20 minutes of the start of the migraine.
The triptans include sumatriptan (Imitrex), rizatriptan (Maxalt), naratriptan (Amerge), zolmitriptan (Zomig), eletriptan (Relpax), lmotriptan (Axert), and frovatriptan (Frova).
A class of drugs introduced in the 1990s for the treatment of migraine that act as agonists for 5-hydroxytryptamine (5-HT) receptors. The triptans are often very effective in relieving migraine but do not prevent future attacks or lessen their frequency. Migraine is believed to be due to dilatation of cranial blood vessels and the release […]
Fear of the number 13. Written reference to this fear dates to the late 1800s. The term triskaidekaphobia appeared in the early 1900s. It is not easy to pronounce unless one speaks Greek. From treiskaideka, the Greek word for thirteen + phobia, fear of = a fear of thirteen.
Inability to open the mouth fully. This may be due to spasm of the jaw muscles and be a symptom of tetanus (lockjaw). Or it may be due to abnormally short jaw muscles, as in the trismus-pseudocamptodactyly syndrome.
The presence of three copies of a chromosome rather than the normal two. The most common trisomies in newborns are trisomy 13 (Patau syndrome), trisomy 18 (Edwards syndrome), and trisomy 21 (Down syndrome).
- Trisomy 13 syndrome
The presence of three copies of chromosome 13, rather than the normal two. Children with trisomy 13 syndrome are profoundly mentally retarded and have multiple malformations, commonly including scalp defects, hemangiomas (blood vessel malformations) of the face and nape of the neck, cleft lip and palate, malformations of the heart and abdominal organs, and flexed […]