TTP (thrombotic thrombocytopenic purpura)
A life-threatening disease involving embolism and thrombosis (plugging) of the small blood vessels in the brain. It is usually caused by inhibition of an enzyme called ADAMTS13 which normally serves to break up a blood protein called Von Willebrand Factor into smaller pieces. TTP is characterized by platelet microthrombi (tiny traveling clots composed of platelets, the clotting cells in the blood), thrombocytopenia (lack of platelets), hemolytic anemia (from the breakup of red blood cells), fever, renal (kidney) abnormalities and neurologic changes such as neurological signs such as aphasia, blindness, and convulsions.
TTP is fortunately rare. It occurs at a rate of 3.7 cases per year per million persons. The use of plasma exchange (running blood through a machine to which the patient is connected which removes the plasma or fluid portion of the blood and returns the cells mixed with new plasma from donors and other fluids) has greatly reduced the death rate from TTP. The mortality (death) rate for promptly treated cases ranges from 10 to 20 percent, down from 90% before the use of plasma exchange technique.
Many drugs have been associated with TTP. One is the antiplatelet drug clopidogrel (Plavix).
The gene that encodes transthyretin, a plasma protein consisting of 127 amino acids that binds retinol and thyroxine. Many distinct forms of amyloidosis have been related to different point mutations in TTR.
- Tubal pregnancy
Pelvic inflammatory disease (PID) which can damage the tube’s functioning or leave it partly or completely blocked; Surgery on a Fallopian tube; Surgery in the neighborhood of the Fallopian tube which can leave adhesions (bands of tissue that bind together surfaces); A prior tubal pregnancy; A history of repeated induced abortions; A history of infertility […]
Please describe your experience with ectopic pregnancy. View 3 Comments • Submit » Causes of bleeding during the first trimester of pregnancy Examples of causes of bleeding during the first trimester of pregnancy are ectopic pregnancy, cervical polyps, or pelvic or urinary tract infection (UTI). Read more about bleeding during pregnancy and when to call […]
A long hollow cylinder. There are many tube-like structures in the human body, such as the auditory tube (Eustachian tube) in the ear.
- Tube, auditory
the upper part called the nasopharynx, the middle part called the oropharynx, and the lower part called the hypopharynx. The Eustachian tube opens into the nasopharynx. The Eustachian tube measures only 17-18mm and is horizontal at birth. As it grows to double that length, it grows to be at an incline of 45 degrees in […]