Genes that make someone susceptible to developing tuberculosis (TB) when exposed to the bacterium (Mycobacterium tuberculosis) that causes it.
Although there are millions of new cases of TB each year, not everyone exposed to the bacterium becomes infected nor does everybody infected with it develop clinical symptoms of TB.
A genetic region has been discovered to be associated with clinical TB. People with at least one high-risk copy of this genetic region are ten times more likely to develop TB than normal. The genetic region contains a gene, NRAMP1, that is known to be involved in the susceptibility to leprosy, which is caused by a bacterium related to TB.
- Tuberculosis, miliary
The presence of numerous sites of tuberculosis (TB) infection, each of which is minute. Miliary TB is caused by dissemination of infected material through the bloodstream.
- Tuberculosis, pulmonary
Tuberculosis (TB) in the lungs. Pulmonary TB is the most common form of active tuberculosis. It can be easily transmitted to others when someone who has it coughs.
Pertaining to tuberculosis. Affected by tuberculosis. Caused by Mycobacterium tuberculosis. As in tuberculous meningitis. Also called tubercular and tuberculotic.
- Tuberculous diskitis
A tuberculosis infection of the spine that is seen most often in children. The main symptom is back pain. Untreated tuberculous diskitis can lead to inward or outward curvature of the spine. Imaging of the spine can find abscesses, some of which may have ossified (hardened). Also known as Pott’s disease. Treatment involves antibiotics for […]
- Tuberculous meningitis
Meningitis due to tuberculosis. Tuberculous meningitis is the most severe form of tuberculosis. It causes severe neurologic deficits or death in more than half of cases. The pattern of tuberculous meningitis in the population is different in different areas of the world. In areas with much tuberculosis, tuberculous meningitis usually affects young children. It develops […]