A genetic disorder characterized by thickening (hyperkeratosis) of the palms and soles, white patches in the mouth (oral leukoplakia), and a very high risk of esophageal cancer. This is the only genetic syndrome known to predispose to squamous cell carcinoma of the esophagus. The risk of developing esophageal cancer is 95% by age 70. The syndrome is inherited in an autosomal dominant manner. The gene has been mapped to chromosome 17q25 but has not been identified. The syndrome is also called nonepidermolytic palmoplantar keratoderma.
1. Pertaining to the tympanum (the eardrum). 2. Pertaining to the tympanic cavity. 3. Bell-like or resonant.
- Tympanic cavity
The major portion of the middle ear, consisting of a narrow air-filled cavity in the temporal bone that contains the bones of the middle ear.
- Tympanic membrane
The eardrum, a thin membrane that serves as a partition between the external ear and the middle ear and transmits the motion of sound waves to the chain of bones in the middle ear.
a distension of the abdomen caused by accumulation of gas in the intestinal tract or peritoneal cavity.
Prefix indicating a relationship to the eardrum (tympanic membrane), as in tympanometry (a test that measures the function of the middle ear).