VACTERL association

V = Vertebral anomalies; and
A = Anal atresia (no hole at the bottom end of the intestine);
C = Cardiac defect, most often ventricular septal defect;
TE = TracheoEsophageal fistula (communication between the esophagus and trachea) with esophageal atresia (part of the esophagus is not hollow);
R = Renal (kidney) abnormalities; and
L = Limb abnormalities, most often radial dysplasia (abnormal formation
of the thumb or the radius bone in the

The VACTERL association has been recurrently observed in newborn babies. It is more common in the children of diabetic mothers than in the general population. For some years that was all that was known about the cause of the VACTERL association. The VACTERL association has been linked to inhibition of cholesterol synthesis and down-regulation (the damping down) of a biochemical pathway in the shaping of the embryo that requires cholesterol. Treatment involves surgery to correct the physical defects, as possible.

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