A genetic disorder characterized by pits of the lower lip and by cleft lip and/or cleft palate. It is the most common known cleft syndrome.
The van der Woude syndrome is highly variable in its expression from person to person. There may be cleft lip, cleft palate, or both. The lip pits may be associated with accessory salivary glands that empty into the pits, leading to visible discharge.
The syndrome is inherited in an autosomal dominant manner. It is due to mutation of the IRF6 gene (interferon regulatory factor 6) on chromosome 1. The same gene is mutated in the popliteal pterygium syndrome, another disorder with cleft lip/palate and lip pits.
- Vanishing bone syndrome
An inherited form of osteolysis — the destruction of bone. There are several such syndromes. In one form of vanishing bone syndrome, there is osteolysis in the hands and feet, crippling arthritic changes in the hands, marked osteoporosis, and nodules beneath the skin of the palms and soles associated with autosomal recessive inheritance. The responsible […]
- Vanishing lung syndrome
“scintigraphy shows a disappearance of perfusion, and angiography shows remnants of arterial branches without the capillary phase. Inside there may be growing an abandoned room.”
- Vanishing twin
A twin detected in early pregnancy that is miscarried, frequently by resorption, without clinical signs or symptoms. The surviving twin continues to grow and develop.
A vaccine against hepatitis A made of killed hepatitis A virus to stimulate the body’s immune system to produce antibodies against the hepatitis A virus.
- Varco, Richard L.
Innovative American surgeon (1912-2004) who helped perform the first successful open heart operation. On Sept. 2, 1952 at the University of Minnesota. Dr. Varco’s team, led by Dr. C. Walton Lillehei and Dr. F. John Lewis, cut off the flow of blood to the heart after lowering the patient’s body temperature to protect her brain. […]